L-2-Hydroxyglutaric acid (disodium)
(2S)-2-Hydroxyglutaric Acid Disodium Salt
CAS: 63512-50-5
Molecular Formula: C5H6O5Na2
L-2-Hydroxyglutaric acid (disodium) - Names and Identifiers
L-2-Hydroxyglutaric acid (disodium) - Physico-chemical Properties
| Molecular Formula | C5H6O5Na2 |
| Melting Point | >300°C |
| Solubility | Methanol (Very Slightly), Water (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| BRN | 5318042 |
| Storage Condition | 2-8°C |
| In vitro study | L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes. |
L-2-Hydroxyglutaric acid (disodium) - Risk and Safety
| WGK Germany | 3 |
L-2-Hydroxyglutaric acid (disodium) - Reference Information
| biological activity | L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and tumor metabolite presumed in kidney cancer, which inhibits histone demethylases and thus promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK), with corresponding Km and Ki values of 2.52 mM and 11.13 mM respectively. |
| target | TargetValue Histone Demethylase () Mi-CK (Cell-free assessment) 2.52 mM(Km) Mi-CK (Cell-free assessment) 11.13 mM(Ki) |
| Target | Value |
| Histone Demethylase () | |
| Mi-CK (Cell-free assay) | 2.52 mM(Km) 11.13 mM(Ki) |
| in vitro study | L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes. |
Last Update：2024-04-10 22:29:15
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